Tag Archives: Duchene Muscular Dystrophy

Duchene Muscular Dystrophy

J Musculoskelet Neuronal Interact. 2013 Mar;13(1):13-8.

Whole body vibration therapy in patients with Duchenne muscular dystrophy – a prospective observational study.

Söderpalm AC, Kroksmark AK, Magnusson P, Karlsson J, Tulinius M, Swolin-Eide D.

Source

Department of Orthopedics, Institute of Clinical Sciences, Sahlgrenska University Hospital/Östra, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden. ann-charlott.soderpalm@vgregion.se

Abstract

OBJECTIVES:

To study the tolerability of whole body vibration (WBV) exercise in patients with Duchenne muscular dystrophy (DMD) and its effects on muscle and bone.

METHODS:

WBV was performed two to three times a week for three months. Motor function, muscle strength, bone mass and biochemical markers of bone and mineral metabolism were analyzed before and after the WBV period at 0, 3, 6 and 12 months.

RESULTS:

Six ambulatory patients with DMD aged 5.7-12.5 years completed the study. No changes in creatine kinase activity were found, indicating that the WBV exercise did not further damage the skeletal muscle. No significant changes in bone mass, muscle strength or bone markers were found. However, there was a non-significant trend for the bone formation marker, bone-specific alkaline phosphate, to increase from a mean of 59 U/L to 73 U/L after three months of WBV. The bone formation marker levels returned to baseline three months after discontinuing WBV and were still at that level after nine months.

CONCLUSIONS:

WBV therapy appears to be safe and well tolerated among ambulatory DMD patients. The potential benefits of WBV on bone and muscle in DMD remain to be elucidated.

PMID: 23445910

Galileo Well Tolerated with Duchenne Muscular Dystrophy

Vibration therapy tolerated in children with Duchenne muscular dystrophy: a pilot study.
Pediatr Neurol. 2014 Jul;51(1):126-9
Myers KA1, Ramage B2, Khan A3, Mah JK4.

Abstract

BACKGROUND:
Duchenne muscular dystrophy is an X-linked recessive muscular dystrophy. Clinical management primarily involves rehabilitation strategies aimed at preserving functional mobility as long as possible. Side-alternating vibration therapy is a rehabilitation intervention that has shown promise in a number of different neuromuscular disorders, and has the potential to preserve strength, functional mobility, and bone mass. There has been little research regarding the tolerance to side-alternating vibration therapy in muscle diseases such as Duchenne muscular dystrophy.

METHODS:
Four patients were recruited for a pilot study assessing the safety and tolerance of side-alternating vibration therapy in individuals with Duchenne muscular dystrophy. All patients participated in a 4-week training period involving side-alternating vibration therapy sessions three times per week. Serum creatine kinase was measured, and adverse effects reviewed at each session with functional mobility assessed before and after the training period.

RESULTS:
All patients tolerated the training protocol well, and there were no major changes in functional mobility. One patient had a transient increase in creatine kinase during the study; however, levels of this enzyme were stable overall when comparing the pretraining and posttraining values. Some patients reported subjective improvement during the training period.

CONCLUSIONS:
Side-alternating vibration therapy is well tolerated in children with Duchenne muscular dystrophy and may have potential to improve or maintain functional mobility and strength in these patients.

Copyright © 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Duchenne muscular dystrophy; rehabilitation; safety; side-alternating vibration therapy; whole-body vibration therapy
PMID: 24830767 [PubMed – indexed for MEDLINE]